The University of Texas Medical School at Houston Department of Psychiatry & Behavioral Sciences
Department of Psychiatry and Behavioral Sciences


Our faculty and staff are in the forefront of the exploration of the causes and treatments of psychiatric disorders.

Jair C. Soares, M.D.



M.D., 1990 Medicine University of São Paulo Medical School, São Paulo, Brazil

Internship, 1993-1994 Internal Medicine and Psychiatry UPMC Health System, Western Psychiatric Institute and Clinic, Pittsburgh, PA

Residency, 1991-1993 Adult Psychiatry University of São Paulo, Institute of Psychiatry, São Paulo, Brazil   

1994-1997 Psychiatry (Research Track) UPMC Health System, Western Psychiatric Institute and Clinic, Pittsburgh, PA

Post Doctoral Fellowship, 1997-1999 Neuroimaging Yale University School of Medicine, New Haven, CT

Clinical and Research Interests:

  1. Brain Imaging
  2. Clinical Psychopharmacology
  3. Mood Disorders

Recent Publications (selected):

  1. Olvera RL, Fonseca M, Caetano SC, Hatch JP, Hunter K, Nicoletti M, Pliszka SR, Cloninger CR, Soares JC. Assessment of personality dimensions in children and adolescents with bipolar disorder using the Junior Temperament and Character Inventory. J Child Adolesc Psychopharmacol. 2009;19(1):13-21.
  2. Nery FG, Chen HH, Hatch JP, Nicoletti MA, Brambilla P, Sassi RB, Mallinger AG, Keshavan MS, Soares JC. Orbitofrontal cortex gray matter volumes in bipolar disorder patients: a region-of-interest MRI study. Bipolar Disord. 2009;11(2):145-53. 8
  3. Nery FG, Hatch JP, Nicoletti MA, Monkul ES, Najt P, Matsuo K, Cloninger CR, Soares JC. Temperament and character traits in major depressive disorder: influence of mood state and recurrence of episodes. Depress Anxiety. 2009.
  4. Matsuo K, Nicoletti M, Nemoto K, Hatch JP, Peluso MA, Nery FG, Soares JC. A voxel-based morphometry study of frontal gray matter correlates of impulsivity. Hum Brain Mapp. 2009;30(4):1188-95.
  5. Matsuo K, Walss-Bass C, Nery FG, Nicoletti MA, Hatch JP, Frey BN, Monkul ES, Zunta-Soares GB, Bowden CL, Escamilla MA, Soares JC. Neuronal Correlates of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Morphometric Abnormalities in Bipolar Disorder. Neuropsychopharmacology. 2009.
  6. Kathleen Holmes M, Bearden CE, Barguil M, Fonseca M, Serap Monkul E, Nery FG, Soares JC, Mintz J, Glahn DC. Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse. Bipolar Disord. 2009;11(1):33-40.
  7. Nery FG, Monkul ES, Hatch JP, Fonseca MM, Zunta-Soares GB, Frey BN, Bowden CL, Soares JC. Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study. Hum Psychopharmacol. 2008;23(2):87-94.
  8. Nery FG, Hatch JP, Glahn DC, Nicoletti MA, Monkul ES, Najt P, Fonseca MM, Bowden CL, Cloninger CR, Soares JC. Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders. J Psychiatr Res. 2008;42(7):569-77.
  9. Nery FG, Borba EF, Viana VS, Hatch JP, Soares JC, Bonfa E, Neto FL. Prevalence of depressive and anxiety disorders in systemic lupus erythematosus and their association with anti-ribosomal P antibodies. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(3):695-700.
  10. Monkul ES, Hatch JP, Sassi RB, Axelson D, Brambilla P, Nicoletti MA, Keshavan MS, Ryan ND, Birmaher B, Soares JC. MRI study of the cerebellum in young bipolar patients. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(3):613-9.
  11. Matsuo K, Rosenberg DR, Easter PC, MacMaster FP, Chen HH, Nicoletti MA, Caetano SC, Hatch JP, Soares JC. Striatal volume abnormalities in treatment-naive patients diagnosed with pediatric major depressive disorder. J Child Adolesc Psychopharmacol. 2008;18(2):121-31.
  12. Machado-Vieira R, Soares JC, Lara DR, Luckenbaugh DA, Busnello JV, Marca G, Cunha A, Souza DO, Zarate CA, Jr., Kapczinski F. A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania. J Clin Psychiatry. 2008;69(8):1237-45.
  13. Joseph MF, Frazier TW, Youngstrom EA, Soares JC. A quantitative and qualitative review of neurocognitive performance in pediatric bipolar disorder. J Child Adolesc Psychopharmacol. 2008;18(6):595-605.
  14. Frey BN, Zunta-Soares GB, Caetano SC, Nicoletti MA, Hatch JP, Brambilla P, Mallinger AG, Soares JC. Illness duration and total brain gray matter in bipolar disorder: Evidence for neurodegeneration? Eur Neuropsychopharmacol. 2008.
  15. Chen HH, Rosenberg DR, MacMaster FP, Easter PC, Caetano SC, Nicoletti M, Hatch JP, Nery FG, Soares JC. Orbitofrontal cortex volumes in medication naive children with major depressive disorder: a magnetic resonance imaging study. J Child Adolesc Psychopharmacol. 2008;18(6):551-6.
  16. Brambilla P, Hatch JP, Soares JC. Limbic changes identified by imaging in bipolar patients. Curr Psychiatry Rep. 2008;10(6):505-9.
  17. Belardinelli C, Hatch JP, Olvera RL, Fonseca MM, Caetano SC, Nicoletti MA, Pliszka SR, Soares JC. Family environment patterns in families with bipolar children. J Affect Disord. 2008;107(1-3):299-305.
  18. Bearden CE, Soares JC, Klunder AD, Nicoletti M, Dierschke N, Hayashi KM, Narr KL, Brambilla P, Sassi RB, Axelson D, Ryan N, Birmaher B, Thompson PM. Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2008;47(5):515-25.
  19. Bearden CE, Thompson PM, Dutton RA, Frey BN, Peluso MA, Nicoletti MA, Dierschke NA, Hayashi KM, Klunder AD, Glahn DC, Brambilla P, Sassi RB, Mallinger AG, Soares JC. Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder. Neuropsychopharmacology. 2008;33(6):1229-38.
  20. Zanetti MV, Soloff PH, Nicoletti MA, Hatch JP, Brambilla P, Keshavan MS, Soares JC. MRI study of corpus callosum in patients with borderline personality disorder: a pilot study. Prog Neuropsychopharmacology Biol Psychiatry. 2007;31(7):1519-25.
  21. Peluso MA, Hatch JP, Glahn DC, Monkul ES, Sanches M, Najt P, Bowden CL, Barratt ES, Soares JC. Trait impulsivity in patients with mood disorders. J Affect Disorder. 2007;100(1-3):227-31.
  22. Olvera RL, Caetano SC, Fonseca M, Nicoletti M, Stanley JA, Chen HH, Hatch JP, Hunter K, Pliszka SR, Soares JC. Low levels of N-acetyl aspartate in the left dorsolateral prefrontal cortex of pediatric bipolar patients. J Child Adolescent Psychopharmacology. 2007;17(4):461-73.
  23. Nery FG, Borba EF, Hatch JP, Soares JC, Bonfa E, Neto FL. Major depressive disorder and disease activity in systemic lupus erythematosus. Compr Psychiatry. 2007;48(1):14-9.
  24. Najt P, Nicoletti M, Chen HH, Hatch JP, Caetano SC, Sassi RB, Axelson D, Brambilla P, Keshavan MS, Ryan ND, Birmaher B, Soares JC. Anatomical measurements of the orbitofrontal cortex in child and adolescent patients with bipolar disorder. Neurosci Lett. 2007;413(3):183-6.
  25. Monkul ES, Hatch JP, Nicoletti MA, Spence S, Brambilla P, Lacerda AL, Sassi RB, Mallinger AG, Keshavan MS, Soares JC. Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Mol Psychiatry. 2007;12(4):360-6.


Faculty Biography

Jair C. Soares, M.D. Department Chair
  • Dr. Jair C. Soares
    Professor and Chair
  • Department of Psychiatry and Behavioral Sciences
  • University of Texas-Houston Medical School
    1941 East Rd Ste. 3210
    Houston, Texas 77054
  • phone: (713) 486-2507
    fax: (713) 486-2553
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